Our lab primarily focuses on bioinformatics, health informatics and integrative analyses. We use high-throughput technologies to examine and model molecular mechanisms of biological processes.
The Kolker Lab at the Seattle Children's Research Institute uses approaches such as genome-wide gene, protein, and metabolite expression, complemented with mutagenesis, biochemical, and physiological experiments. Integration and analysis of these multivariate data will be implemented through comprehensive computations, including bioinformatics, statistics, and mathematical modeling. The deeper knowledge of cellular behavior and responses will enable the researches at the Kolker Lab to develop improvements to human health and address environmental concerns.
- Software and statistical methods for the analysis of proteomics data
- SPIRE (Systematic Protein Investigative Research Environment)
- Web application for teens with diabetes
- Experimental standards for high-throughput proteomics
- Web Predictive analytics to improve hospital care and management
- Functional annotation of proteins
- Integrative studies of clinical samples and model systems