Recent advances in scientific technology have left us confronted with the task of discovering scientific knowledge from enormous amounts of data generated in the life and environmental sciences, physics and sociology, business and medicine. The first Data-Intensive Sciences Workshop will start with three inspirational talks on this challenge by Alex Szalay (Astronomy, John Hopkins University), and Blake Nordstrom (President of Nordstrom). After these talks, participants will assemble into small working groups. Discussions will be organized around several focus areas and will address the availability and limitations of current resources and policies as well as their role as future enablers of data-intensive biomedical and life sciences and more. Questions include: “How to enable analysis and management of large-scale data sets?”. We will also delve into “What objectives would you like to achieve in 3, 5 and 10 years with regard to large data set generation and distribution, analysis and integration?” and “What biomedical and life sciences data-intensive capabilities do you envision in 3, 5 and 10 years?”. Furthermore, we will ask other broad questions such as “How can we leapfrog current biomedical and life sciences practices to cutting-edge data-intensive approaches achieved in other industrial and academic areas?”. The key result of this first workshop will be publication of submitted perspective statements and gaps analysis document.